The mystery grows -- and a conspiracy forms! Agents Kearse and Gray travel to San Francisco, where the "Sanctuary" movement -- in which churches provide safe haven for mutants -- has been targeted by extremists. There, they will encounter four strange young girls -- and the mutants who are trying to save them. And as the two agents dig deeper into the mutant subculture, they're forced to confront unpleasant truths --- about themselves!
— Description from Comic Vine community (comicvine.gamespot.com).