Yamada Asaemon, the Shogun's executioner and sword tester, is on the scene to help Burando accelerate the pace of his sadistic medical experiments to discover the secret of Manji's immortality. Still chained in a prison near Edo castle, Manji stews and ponders his next escape attempt. With Manji's old cellmate, Dewanosuke, recovering and possibly benefiting from Burando's schemes, will he help Manji regain his freedom or will Dewanosuke become enticed by the allure of immortality and rally to the side of Manji's captors? This issue also features a color Blade of the Immortal pinup by Samura fan Becky Cloonan.
